around, piers, is the number. usually not life-threatening. simply, piers, what happens is there's a lot of release of different hormones at the time that someone becomes pregnant, and around eight or nine weeks usually into the pregnancy is when those hormones actually become -- start affecting the nausea centers, if you will, in the brain. i can tell you, it's very profound, meaning that you simply cannot keep anything down. you try and give someone medications, pills, for example, to control nausea and they simply can't keep it down and that's typically what leads to the hospitalization. they need to get those iv fluids replaced. about 20% of these women who have this condition need a feeding tube put in. so again, not typically life-threatening, but very serious and women who have had a history of motion sickness, women who have had a history of migraines, have had a family history of this sort of thing, they are most at risk. as you mentioned just now, women who are carrying multiples as well. but you know, typically it's treated but it's a few pretty awful weeks, piers.